Description

4-Chloro-2-Methylthiopyrimidine is a versatile halogenated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its dual functionalization, featuring a reactive chlorine atom and a methylthio group, which allows for selective derivatization to create complex molecular architectures. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used as a building block for creating novel herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and organic electronic materials.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & R&D: Utilized in university and corporate research laboratories for methodological development and exploring new chemical reactions.

Basic Information

Product Name	4-Chloro-2-Methylthiopyrimidine
CAS No.	49844-90-8
Molecular Formula	C5H5ClN2S
Molecular Weight	160.62 g/mol
Synonyms	2-(Methylthio)-4-chloropyrimidine; 4-Chloro-2-(methylthio)pyrimidine; 4-Chloro-2-methylsulfanylpyrimidine; 4-Chloro-2-methylmercaptopyrimidine; 2-Methylthio-4-chloropyrimidine; 4-Chloro-2-(methylsulfanyl)pyrimidine; 4-Chloro-2-(methylthio)-pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Methylthiopyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.