Description

Tobramycin Sulfate is the sulfate salt form of tobramycin, a potent aminoglycoside antibiotic. This compound is critical for its broad-spectrum bactericidal activity, particularly against Gram-negative pathogens. It is an essential active pharmaceutical ingredient (API) for the formulation of injectable and ophthalmic pharmaceutical products. Global pharmaceutical manufacturers and research institutions rely on high-purity tobramycin sulfate to develop effective antimicrobial therapies.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations for systemic infections.
• Ophthalmic Solutions: Key component in eye drops and ointments for treating bacterial conjunctivitis and other ocular infections.
• Veterinary Medicine: Used in antimicrobial preparations for treating bacterial infections in animals.
• Research & Development: Serves as a reference standard and raw material in microbiological and pharmacological research.
• Respiratory Therapy: Used in nebulized solutions for managing chronic pulmonary infections in conditions like cystic fibrosis.
• Topical Formulations: Incorporated into creams and gels for localized skin and wound infections.

Basic Information

Product Name	Tobramycin Sulfate
CAS No.	49842-07-1
Molecular Formula	C18H37N5O9 · xH2SO4
Molecular Weight	467.52 (for tobramycin base) + H2SO4
Synonyms	Tobramycin Sulphate; Nebcin; TOBI; TobraDex (component); (2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R,4S,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol sulfate; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxy-D-streptamine sulfate; Gernebcin; Tobramycin Sulfate Salt
EINECS	256-508-5

Quality Control

Our Tobramycin Sulfate is manufactured and tested under strict quality systems. It meets stringent specifications for pharmaceutical applications, with testing aligned to pharmacopeial standards such as USP and EP. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and impurity profiles to ensure compliance and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (Anhydrous Basis)	90.0% - 102.0%
pH (1% Solution)	4.0 - 6.0
Water Content (KF)	≤ 8.0%
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Bacterial Endotoxins	< 1.0 EU/mg
Sterility (if applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.