Description

cis-Thiothixene Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is critical for the research, development, and production of neuroleptic medications. It is primarily required by pharmaceutical manufacturers and advanced research institutions focused on central nervous system (CNS) therapeutics.

Application

• Pharmaceutical API Synthesis: Primary use as an active ingredient in the manufacture of antipsychotic medications.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical labs.
• Pharmacological Research: Used in preclinical and clinical studies to investigate mechanisms of action and therapeutic efficacy.
• Process Development: Employed in the optimization of scalable synthesis routes for commercial drug production.
• Impurity Profiling: Acts as a key marker in HPLC and related chromatographic methods to identify and quantify related substances.
• Formulation Development: Utilized in the development of stable and bioavailable dosage forms.

Basic Information

Product Name	cis-Thiothixene Hydrochloride
CAS No.	49746-04-5
Molecular Formula	C23H29N3O2S2·HCl
Molecular Weight	492.08 g/mol
Synonyms	cis-Thiothixene HCl; (Z)-Thiothixene Hydrochloride; (Z)-N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide Hydrochloride; Tiotixene Hydrochloride; Navane (as the API); CP-12252-1; 9-[3-(4-Methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide Hydrochloride (cis-isomer)
EINECS	Contact for details

Quality Control

Our cis-Thiothixene Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.