Description

Z-Glu(Obzl)-Onp is a protected amino acid derivative, specifically the p-nitrophenyl ester of N-benzyloxycarbonyl-L-glutamic acid. This compound serves as a crucial activated intermediate in peptide synthesis, enabling the efficient and selective formation of peptide bonds under mild conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the controlled incorporation of glutamic acid residues.
• Solution-Phase Peptide Coupling: Facilitating the synthesis of peptide fragments and small oligopeptides in solution.
• Bioconjugation: Used for the site-specific labeling or functionalization of proteins, antibodies, and other biomolecules.
• Medicinal Chemistry Research: A key building block in the discovery and optimization of peptide-based therapeutics and diagnostic agents.
• Chemical Biology Probes: Synthesis of activity-based probes and substrates for studying enzyme function.
• Material Science: Potential use in the synthesis of peptide-polymer conjugates and functionalized surfaces.

Basic Information

Product Name	Z-Glu(Obzl)-Onp
CAS No.	49689-66-9
Molecular Formula	C₂₂H₂₄N₂O₈
Molecular Weight	444.44 g/mol
Synonyms	N-Cbz-L-glutamic acid α-benzyl ester p-nitrophenyl ester; Nα-Benzyloxycarbonyl-L-glutamic acid 1-benzyl ester 5-(4-nitrophenyl) ester; Z-Glu(OBzl)-ONp; Cbz-Glu(OBzl)-ONp; (S)-5-(Benzyloxy)-4-((((benzyloxy)carbonyl)amino)-5-oxopentanoic acid 4-nitrophenyl ester; L-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 1-(phenylmethyl) ester, 5-(4-nitrophenyl) ester; Z-L-Glutamic acid α-benzyl ester p-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Z-Glu(Obzl)-Onp is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in DMF)
Melting Point	98°C - 102°C
Heavy Metals (as Pb)	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.