Description

4-(Difluoromethyl)Aniline is a versatile fluorinated aromatic amine building block, essential for introducing the difluoromethyl aniline moiety into complex molecular architectures. Its value lies in enabling the synthesis of advanced materials and active compounds with tailored properties, such as enhanced metabolic stability and lipophilicity. This intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for creating novel drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the difluoromethyl group can improve bioactivity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated as a monomer or additive to impart specific chemical resistance, stability, or surface properties to advanced polymers.
• Dye & Pigment Manufacturing: Acts as a starting material for producing specialized fluorinated dyes and pigments with unique color fastness and properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex aryl amine structures.

Basic Information

Product Name	4-(Difluoromethyl)Aniline
CAS No.	49658-26-6
Molecular Formula	C7H7F2N
Molecular Weight	143.13 g/mol
Synonyms	4-(Difluoromethyl)benzenamine; 4-Aminobenzylidene Difluoride; p-(Difluoromethyl)aniline; Benzenamine, 4-(difluoromethyl)-; 4-(Difluoromethyl)phenylamine; 1-Amino-4-(difluoromethyl)benzene; α,α-Difluoro-p-toluidine
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)Aniline is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.