Description

L-Cyclobutylglycine is a non-proteinogenic amino acid derivative featuring a cyclobutyl side chain. This chiral building block is of significant value in pharmaceutical research and development, particularly for the synthesis of novel peptide-based therapeutics and enzyme inhibitors. It serves as a critical intermediate for medicinal chemists and R&D teams in the pharmaceutical, biotechnology, and fine chemical sectors seeking to modulate the pharmacokinetic properties and biological activity of new drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, peptidomimetics, and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce conformational constraints and enhance metabolic stability.
• Biochemical Research: Serves as a substrate analog or inhibitor in enzymatic studies and metabolic pathway investigations.
• Asymmetric Synthesis: Employed as a building block in the synthesis of complex natural products and non-natural amino acid libraries.
• Prodrug Design: Utilized in the structural modification of drug molecules to improve solubility, bioavailability, or targeting.
• Agrochemical Research: Potential application in the synthesis of novel herbicides or plant growth regulators with specific chiral requirements.

Basic Information

Product Name	L-Cyclobutylglycine
CAS No.	49607-08-1
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(S)-2-Amino-2-cyclobutylacetic acid; L-2-Cyclobutylglycine; (S)-2-Cyclobutylglycine; (S)-Amino(cyclobutyl)acetic acid; H-Cyg(But)-OH; Cyclobutylglycine, L-; L-α-Aminocyclobutaneacetic acid
EINECS	Contact for details

Quality Control

Our L-Cyclobutylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided to guarantee consistent quality, identity, and purity for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.