Description

7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-1-(2,2,2-Trifluoroethyl)-2H-1,4-Benzodiazepin-2-One is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel therapeutic agents, particularly within the central nervous system (CNS) drug discovery pipeline. It is essential for pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel benzodiazepine analogs and other bioactive molecules.
• Neurological Research: Used in preclinical studies targeting GABA-A receptor modulation for potential anxiolytic, sedative, or anticonvulsant applications.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Reference Standard: Employed as an analytical standard in quality control (QC) and method development for related active pharmaceutical ingredients (APIs).
• Process Development: Utilized in scaling up synthetic routes and optimizing manufacturing processes for clinical trial material (CTM) production.
• Contract Synthesis: Supplied to CROs and CDMOs for custom synthesis projects requiring this specific fluorinated benzodiazepine core.

Basic Information

Item	Details
Product Name	7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-1-(2,2,2-Trifluoroethyl)-2H-1,4-Benzodiazepin-2-One
CAS No.	49606-44-2
Molecular Formula	C₁₇H₁₁ClF₄N₂O
Molecular Weight	370.73 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Ro 07-4065; 7-Chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-; Ro07-4065
EINECS	Contact for details

Quality Control

Our 7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-1-(2,2,2-Trifluoroethyl)-2H-1,4-Benzodiazepin-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.