Description

Amikacin B is a potent semi-synthetic aminoglycoside antibiotic derived from kanamycin A. This compound is critical for its broad-spectrum bactericidal activity, particularly against Gram-negative bacteria, including many resistant strains. It is an essential intermediate in the synthesis of the final active pharmaceutical ingredient, Amikacin sulfate, serving the needs of the global pharmaceutical manufacturing and research sectors. Our supply of Amikacin B CAS NO 48237-20-3 ensures high purity and reliable consistency for critical production processes.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of Amikacin sulfate, a vital injectable antibiotic.
• Active Pharmaceutical Ingredient (API) Manufacturing: Sourced by API producers for the commercial-scale production of finished antibiotic formulations.
• Research & Development: Utilized in microbiological research, mechanism of action studies, and the development of new antibacterial agents.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical testing in laboratories.
• Veterinary Medicine: Potential application in the development of antibacterial treatments for animal health.

Basic Information

Product Name	Amikacin B
CAS No.	48237-20-3
Molecular Formula	C22H43N5O13
Molecular Weight	585.61 g/mol
Synonyms	O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine; 1-N-[(S)-4-Amino-2-hydroxybutyryl]-kanamycin B; Antibiotic BB-K 8; Amikacin B base; Kanamycin B 1-N-(4-amino-2-hydroxybutyryl) derivative
EINECS	Contact for details

Quality Control

Our Amikacin B is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical intermediates. Quality is verified through comprehensive analytical testing, including HPLC for purity and identity confirmation. While produced to meet general chemical and in-house specifications, it is suitable for use in GMP-compliant processes upon qualification. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.