Description

Angiotensin I/II (1-6) is a bioactive peptide fragment derived from the renin-angiotensin system, a key regulator of blood pressure and fluid balance. This specific hexapeptide sequence is crucial for research into cardiovascular physiology, enzyme kinetics, and receptor-ligand interactions. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers focused on metabolic and hypertensive disorders.

Application

• Biochemical Research: Used as a reference standard or substrate in studies of the renin-angiotensin-aldosterone system (RAAS) and angiotensin-converting enzyme (ACE) activity.
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the research and development of cardiovascular drugs, including ACE inhibitors and angiotensin receptor blockers (ARBs).
• Diagnostic Assays: Employed in the calibration and development of immunoassays (e.g., ELISA) for measuring angiotensin peptides in biological samples.
• Enzyme Kinetics Studies: Acts as a specific substrate to investigate the catalytic mechanisms and inhibition profiles of proteolytic enzymes like ACE and other peptidases.
• Cell Signaling Research: Utilized in in vitro studies to explore cellular responses, receptor binding, and signal transduction pathways related to angiotensin fragments.
• Peptide Chemistry: Functions as a building block or model compound in peptide synthesis and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Angiotensin I/II (1-6)
CAS No.	47896-63-9
Molecular Formula	C₃₄H₅₀N₁₀O₈
Molecular Weight	726.83 g/mol
Synonyms	Angiotensin I (1-6); Angiotensin II (1-6); Asp-Arg-Val-Tyr-Ile-His; DRVYIH; H-Asp-Arg-Val-Tyr-Ile-His-OH; Angiotensin Hexapeptide; [Asp1, Arg2, Val3, Tyr4, Ile5, His6]-Angiotensin I/II
EINECS	Contact for details

Quality Control

Every batch of Angiotensin I/II (1-6) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), peptide content, and amino acid analysis is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.