Description

Trt-Val-Oh CAS NO 47522-06-5 is a protected amino acid derivative, specifically N-(tert-Butoxycarbonyl)-L-valine, which serves as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing a chiral valine residue with the α-amino group protected by the acid-labile Boc group, enabling precise, sequential peptide chain assembly. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research biochemicals.

Application

• Pharmaceutical Intermediates: Key raw material for the synthesis of complex peptide active pharmaceutical ingredients (APIs).
• Solid-Phase Peptide Synthesis (SPPS): Used as a Boc-protected amino acid for the automated, sequential construction of peptide chains on resin.
• Research & Development: Employed in academic and industrial labs for developing new peptide sequences with potential biological activity.
• Bioconjugation: Serves as a linker or spacer molecule in the creation of peptide-drug conjugates or labeled peptides.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening of peptide candidates.
• Custom Peptide Services: Supplied to CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Trt-Val-Oh CAS NO 47522-06-5
CAS No.	47522-06-5
Molecular Formula	C₁₀H₁₉NO₄
Molecular Weight	217.26 g/mol
Synonyms	Boc-L-Valine; N-(tert-Butoxycarbonyl)-L-valine; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid; Boc-Val-OH; N-Boc-L-valine; N-tert-Butoxycarbonyl-L-valine; 2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-methylbutanoic acid; BOC-Val
EINECS	Contact for details

Quality Control

Our Boc-L-Valine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-3.5° to -5.0° (c=1 in Acetic Acid)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.