Description

L-Histidine Benzyl Ester is a protected derivative of the essential amino acid L-Histidine, where the carboxylic acid group is esterified with benzyl alcohol. This modification is crucial in peptide synthesis, as it masks the reactive acid functionality, preventing unwanted side reactions and allowing for the selective construction of complex peptide chains. It is a vital building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing therapeutic peptides, enzyme inhibitors, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the sequential assembly of peptides on resin.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for producing custom peptides and peptide fragments.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in the study of enzyme mechanisms, receptor-ligand interactions, and protein structure-function relationships.
• Proteomics & Diagnostics: Used to create labeled or modified histidine residues for analytical and diagnostic applications.
• Catalyst & Ligand Development: The imidazole side chain can be utilized in designing metal-chelating ligands and organocatalysts.

Basic Information

Product Name	L-Histidine Benzyl Ester
CAS No.	46921-20-4
Molecular Formula	C13H17N3O2
Molecular Weight	247.29 g/mol
Synonyms	L-Histidine benzyl ester; H-His-OBzl; Benzyl L-histidinate; Histidine benzyl ester; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid benzyl ester; L-Histidine, benzyl ester; NSC 334898; Fmoc-His(Boc)-OBzl (when further protected)
EINECS	Contact for details

Quality Control

Our L-Histidine Benzyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric purity, and identity confirmation (IR, NMR). We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	+10.0° to +14.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.