Description

H-Thr-Pro-Oh CAS NO 46398-79-2 is a high-purity dipeptide derivative composed of L-Threonine and L-Proline. This compound serves as a critical building block and intermediate in advanced pharmaceutical synthesis and peptide research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require reliable, high-quality raw materials for drug development and biochemical studies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex peptide-based active pharmaceutical ingredients (APIs) and novel therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for constructing longer peptide chains with specific sequences.
• Biochemical Research: Serves as a standard or reagent in proteomics research, enzyme-substrate studies, and metabolic pathway analysis.
• Cosmetic Peptides: Potential ingredient in the development of advanced cosmetic peptides for skincare formulations targeting anti-aging or moisturization.
• Nutraceuticals: Investigated for use in specialized nutraceutical products and dietary supplements.
• Chemical Biology Probes: Utilized in the design and synthesis of probes for studying biological processes and protein interactions.

Basic Information

Product Name	H-Thr-Pro-Oh
CAS No.	46398-79-2
Molecular Formula	C9H16N2O4
Molecular Weight	216.23 g/mol
Synonyms	L-Threonyl-L-proline; H-Thr-Pro-OH; Thr-Pro; L-Thr-L-Pro; Threonylproline; 2-[(2S,3R)-2-Amino-3-hydroxybutanoyl]-1-pyrrolidinecarboxylic acid; (S)-2-((2S,3R)-2-Amino-3-hydroxybutanamido)pyrrolidine-1-carboxylic acid; TFA salt of H-Thr-Pro-Oh (common derivative)
EINECS	Contact for details

Quality Control

Our H-Thr-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.