Description

2-Chloro-4-Fluorobenzyl Bromide is a versatile and high-purity halogenated benzyl bromide intermediate essential for advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the aromatic ring, makes it a critical building block for introducing functional complexity into target molecules. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the halogenated benzyl moiety contributes to biological activity and stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for creating complex organic molecules used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An effective electrophile in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, for constructing biaryl and complex amine structures.
• Functional Material Research: Employed in academic and industrial R&D for synthesizing ligands, polymers, and other specialty chemicals with tailored properties.
• Derivatization Agent: Used to introduce the 2-chloro-4-fluorobenzyl protecting group or functional handle onto other molecules in multi-step synthetic pathways.

Basic Information

Product Name	2-Chloro-4-Fluorobenzyl Bromide
CAS No.	45767-66-6
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-(Bromomethyl)-2-chloro-4-fluorobenzene; α-Bromo-2-chloro-4-fluorotoluene; (2-Chloro-4-fluorophenyl)methyl bromide; 2-Chloro-4-fluorobenzylbromide; 2-Chloro-4-fluoro-α-bromotoluene; 2-Chloro-4-fluorobenzyl bromide; 4-Fluoro-2-chlorobenzyl bromide; Benzene, 1-(bromomethyl)-2-chloro-4-fluoro-
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluorobenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. Due to its light-sensitive nature and reactivity, it is recommended to store under an inert atmosphere for long-term stability and to minimize decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.