Description

n-L-Alanyl-L-Glutamic Acid Bis(1,1-Dimethylethyl) Ester is a protected dipeptide derivative, serving as a crucial building block in advanced organic synthesis and peptide chemistry. Its primary value lies in providing a versatile intermediate for the controlled construction of complex peptides and peptidomimetics, where the tert-butyl ester groups offer orthogonal protection for the glutamic acid side chain. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors engaged in developing novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the solid-phase and solution-phase synthesis of therapeutic peptides and protein fragments.
• Bioconjugation & Probe Development: Used in the preparation of labeled peptides for diagnostic assays, imaging probes, and targeted drug delivery systems.
• Peptidomimetic Research: Serves as a precursor in the design and synthesis of non-natural peptide analogs with enhanced stability or biological activity.
• Biochemical Tool Compound: Employed in enzymatic studies and as a substrate or inhibitor in protease and peptidase research.
• Cosmetic Peptide Synthesis: Intermediate for producing certain bioactive peptides used in advanced skincare and cosmetic formulations.
• Academic & Industrial R&D: Fundamental reagent for chemical biology research and process development in fine chemical production.

Basic Information

Product Name	n-L-Alanyl-L-Glutamic Acid Bis(1,1-Dimethylethyl) Ester
CAS No.	45272-19-3
Molecular Formula	C₁₇H₃₀N₂O₆
Molecular Weight	358.43 g/mol
Synonyms	H-Ala-Glu(OtBu)-OtBu; L-Alanyl-L-glutamic acid α,γ-bis(tert-butyl) ester; Ala-Glu(OtBu)-OtBu; N-(tert-Butoxycarbonyl)-L-alanyl-L-glutamic acid 1,5-bis(tert-butyl) ester; Boc-Ala-Glu(OtBu)-OtBu (when N-terminal Boc-protected); (S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)pentanedioic acid bis(tert-butyl) ester; Protected L-Alanyl-L-glutamate
EINECS	Contact for details

Quality Control

Our n-L-Alanyl-L-Glutamic Acid Bis(1,1-Dimethylethyl) Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.