Description

L-Glutamic Acid α-Tert-Butyl Ester is a protected amino acid derivative of fundamental importance in synthetic organic chemistry. This compound serves as a critical building block for the controlled synthesis of peptides and complex organic molecules, enabling advanced research and production. It is primarily utilized by pharmaceutical researchers, biotech companies, and fine chemical manufacturers engaged in developing novel therapeutics and bioactive compounds.

Application

• Peptide Synthesis: A key intermediate in solid-phase and solution-phase peptide synthesis, where the tert-butyl group protects the glutamic acid side chain.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and production of active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Linker Chemistry: Used in the design and synthesis of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted therapies.
• Biochemical Research: Employed in the study of enzyme substrates, receptor ligands, and the preparation of modified peptides for proteomics.
• Fine Chemical Production: Acts as a chiral synthon for the asymmetric synthesis of complex natural products and specialty chemicals.
• Material Science: Potential use in the development of functional polymers and biomaterials with specific amino acid-based properties.

Basic Information

Product Name	L-Glutamic Acid α-Tert-Butyl Ester
CAS No.	45120-30-7
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	L-Glutamic acid 1-tert-butyl ester; (S)-2-Amino-5-tert-butoxy-5-oxopentanoic acid; H-Glu(OtBu)-OH; tert-Butyl L-glutamate; N-(tert-Butoxycarbonyl)-L-glutamic acid; Boc-L-Glu-OH; L-Glutamic acid, α-tert-butyl ester; Glutamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid α-Tert-Butyl Ester is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.