Description

H-D-Ser(Ac)-Oh CAS NO 44901-25-9 is a protected derivative of the amino acid D-serine, featuring an acetyl group on the serine side chain. This modification is crucial for its primary role as a key building block in the solid-phase synthesis of complex peptides and peptidomimetics, where it prevents unwanted side reactions. It is an essential raw material for pharmaceutical R&D, particularly in the development of therapeutic peptides, diagnostic agents, and biochemical research tools.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel therapeutic peptides targeting metabolic disorders, neurological conditions, and oncology.
• Peptide Synthesis: Used in Fmoc/t-Bu solid-phase peptide synthesis (SPPS) to incorporate protected D-serine residues into peptide chains.
• Biochemical Research: Serves as a precursor for studying enzyme-substrate interactions, receptor binding, and structure-activity relationships (SAR) in medicinal chemistry.
• Diagnostic Agent Development: Employed in the creation of radiolabeled peptides or contrast agents for medical imaging applications.
• Glycopeptide Synthesis: Acts as a starting material for the preparation of more complex glycopeptide structures due to its protected hydroxyl group.
• Cosmetic Peptides: A potential ingredient in the synthesis of bioactive peptides for advanced skincare formulations.

Basic Information

Product Name	H-D-Ser(Ac)-Oh
CAS No.	44901-25-9
Molecular Formula	C5H9NO4
Molecular Weight	147.13 g/mol
Synonyms	N-Acetyl-D-serine; D-Serine, N-acetyl-; (R)-2-Acetamido-3-hydroxypropanoic acid; Ac-D-Ser-OH; H-D-Ser(Ac)-OH; D-2-(Acetylamino)-3-hydroxypropanoic acid; N-Acetyl-D-serine, free acid; D-N-Acetylserine
EINECS	Contact for details

Quality Control

Our H-D-Ser(Ac)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the D-configuration, and identity confirmation by IR and NMR. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Specific range provided on COA
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.