Description

(S)-2-Methylproline is a high-value, non-proteinogenic amino acid derivative characterized by its stereospecific (S)-configuration and a methyl-substituted pyrrolidine ring. This compound matters as a versatile and critical chiral building block for the synthesis of complex pharmaceutical intermediates and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptidomimetics, protease inhibitors, and other advanced therapeutic agents where precise stereochemistry is essential for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of drug candidates, particularly for antiviral and anticancer therapies.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity and modify the pharmacokinetic properties of peptide-based drugs.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various enzymes like DPP-4 or HCV NS3/4A protease.
• Asymmetric Synthesis Catalyst Ligand: Can be utilized as a precursor for chiral ligands or organocatalysts in enantioselective transformations.
• Chemical Biology Research: Employed as a tool compound to study enzyme mechanisms or protein-ligand interactions.
• Agrochemical Synthesis: Potential intermediate for creating chiral active ingredients with specific biological activity.

Basic Information

Product Name	(S)-2-Methylproline
CAS No.	42856-71-3
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(2S)-2-Methylpyrrolidine-2-carboxylic acid; L-2-Methylproline; (S)-2-Methyl-2-pyrrolidinecarboxylic acid; (S)-2-Methyl-DL-proline; (S)-α-Methylproline; 2-Methyl-L-proline; (S)-2-Pyrrolidinecarboxylic acid, 2-methyl-; (2S)-2-Methyl-2-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-2-Methylproline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.