Description

4-(Trifluoromethoxy)Aniline Hydrochloride is a high-purity, halogenated aniline derivative salt, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the electron-withdrawing trifluoromethoxy group and the reactive aniline moiety, enabling the construction of complex molecules with tailored properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group contributes to efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display and lighting technologies.
• Dye & Pigment Manufacturing: Intermediate for creating specialized dyes and pigments with improved lightfastness and color properties.
• Polymer Modification: Employed to introduce aniline and fluorinated functionalities into polymer chains for specialty materials.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for creating complex aromatic amines.

Basic Information

Product Name	4-(Trifluoromethoxy)Aniline Hydrochloride
CAS No.	42823-24-5
Molecular Formula	C7H7ClF3NO
Molecular Weight	213.58 g/mol
Synonyms	4-Aminophenyl trifluoromethyl ether hydrochloride; 4-(Trifluoromethoxy)benzenamine hydrochloride; p-(Trifluoromethoxy)aniline hydrochloride; 1-Amino-4-(trifluoromethoxy)benzene hydrochloride; Aniline, 4-(trifluoromethoxy)-, hydrochloride; 4-Trifluoromethoxyaniline HCl; 4-TFMA HCl
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Aniline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (HPLC), related substances, and residual solvents. Our quality commitment supports compliance in cGMP and ISO 9001 environments for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed and protected from humidity. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.