Description

N(5)-Hydroxy-L-Arginine is a modified amino acid derivative of L-arginine, featuring a hydroxyl group at the N(5) position of the guanidino side chain. This structural modification makes it a valuable intermediate and research chemical for studying nitric oxide synthase (NOS) pathways and related biochemical processes. It is primarily utilized by research institutions and pharmaceutical developers focused on cardiovascular, neurological, and metabolic research. The compound is supplied to meet the stringent purity requirements of advanced biochemical applications.

Application

• Biochemical Research: Critical intermediate in the study of nitric oxide (NO) biosynthesis and the enzymatic activity of nitric oxide synthase (NOS) isoforms.
• Pharmaceutical Development: Serves as a key building block or reference standard in the discovery and development of novel therapeutics targeting NO-related pathways.
• Enzyme Inhibition Studies: Used to investigate and characterize NOS inhibitors for potential therapeutic applications in conditions like inflammation and sepsis.
• Metabolic Pathway Analysis: Employed in cell culture and in vitro studies to elucidate the role of arginine derivatives in cellular signaling and metabolism.
• Academic Research: A standard reagent in university and institutional labs for graduate and post-graduate level research in biochemistry and molecular biology.
• Reference Standard: Used as a high-purity calibrant in analytical methods such as HPLC and LC-MS for quantifying related compounds in complex matrices.

Basic Information

Product Name	N(5)-Hydroxy-L-Arginine
CAS No.	42599-90-6
Molecular Formula	C6H14N4O3
Molecular Weight	190.20 g/mol
Synonyms	N5-Hydroxy-L-arginine; NG-Hydroxy-L-arginine; L-N5-Hydroxyarginine; ω-Hydroxy-L-arginine; NOHA; N(omega)-Hydroxy-L-arginine; (2S)-2-Amino-5-[(diaminomethylidene)amino]oxypentanoic acid
EINECS	Contact for details

Quality Control

Our N(5)-Hydroxy-L-Arginine is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.