Description

Z-n-Me-Glu(Otbu)-Oh CAS NO 42417-71-0 is a protected amino acid derivative, specifically an N-benzyloxycarbonyl (Z) protected glutamic acid with a tert-butyl ester side chain and a methyl group on the nitrogen. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure and protecting group strategy. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry and drug discovery programs.

Application

• Peptide Synthesis: Serves as a key protected glutamic acid residue in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs) and therapeutic peptides.
• Bioconjugation: Acts as a precursor for creating linkers and modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme activity.
• Combinatorial Chemistry: A valuable building block for generating diverse chemical libraries for high-throughput screening.

Basic Information

Product Name	Z-n-Me-Glu(Otbu)-Oh
CAS No.	42417-71-0
Molecular Formula	C₁₈H₂₅NO₆
Molecular Weight	351.40 g/mol
Synonyms	N-Benzyloxycarbonyl-N-methyl-L-glutamic acid α-tert-butyl ester; Z-N-Me-Glu(OtBu)-OH; N-Cbz-N-methyl-L-glutamic acid 1-tert-butyl ester; (2S)-2-[[(Benzyloxy)carbonyl](methyl)amino]-5-tert-butoxy-5-oxopentanoic acid; N-Methyl-N-carbobenzoxy-L-glutamic acid γ-tert-butyl ester; Z-N(Me)-Glu(OtBu)-OH; Nα-Cbz-Nα-methyl-L-glutamic acid γ-tert-butyl ester; N-Carbobenzyloxy-N-methyl-L-glutamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Z-n-Me-Glu(Otbu)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.