Description

8-Chloro-6-(2-Chlorophenyl)-4H-[1,2,4]Triazolo[4,3-A][1,4]Benzodiazepine is a high-purity, advanced pharmaceutical intermediate belonging to the triazolobenzodiazepine class of compounds. This compound is critical for research and development in medicinal chemistry, particularly for synthesizing novel therapeutic agents targeting the central nervous system. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel triazolobenzodiazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical labs.
• Preclinical Development: Employed in the production of compounds for pharmacological screening and toxicology studies.
• Academic & Institutional Research: Utilized in university and institutional labs for studying benzodiazepine receptor interactions and related pharmacology.
• Custom Synthesis: A starting material for the custom synthesis of specialized analogs and derivatives for client-specific research programs.

Basic Information

Product Name	8-Chloro-6-(2-Chlorophenyl)-4H-[1,2,4]Triazolo[4,3-A][1,4]Benzodiazepine
CAS No.	42292-42-2
Molecular Formula	C₁₇H₁₀Cl₂N₄
Molecular Weight	341.19 g/mol
Synonyms	8-Chloro-6-(2-chlorophenyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine; 8-Chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine; 42292-42-2; 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-6-(2-chlorophenyl)-; Lopirazepam Impurity; Triazolobenzodiazepine Derivative
EINECS	Contact for details

Quality Control

Our 8-Chloro-6-(2-Chlorophenyl)-4H-[1,2,4]Triazolo[4,3-A][1,4]Benzodiazepine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP guidelines, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.