Description

4-Phosphorylproline is a specialized, high-value amino acid derivative where a phosphoryl group is attached to the proline ring. This unique structural modification makes it a critical intermediate and building block in advanced biochemical research and pharmaceutical development. It is primarily sought after by research institutions and manufacturers in the life sciences sector for applications in peptide synthesis, enzyme studies, and as a precursor for novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel peptide-based drugs and prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, phosphatases, and proline metabolism.
• Peptide Synthesis: Incorporated into custom peptides to study phosphorylation's effects on peptide structure, stability, and biological activity.
• Proteomics & Signal Transduction Studies: A valuable tool for mimicking or blocking phosphorylated proline residues in proteins to investigate cellular signaling pathways.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to develop new chemical entities with targeted therapeutic effects.

Basic Information

Item	Details
Product Name	4-Phosphorylproline
CAS No.	41863-46-1
Molecular Formula	C5H10NO6P
Molecular Weight	211.11 g/mol
Synonyms	L-4-Phosphonoproline; (2S)-1,2-Pyrrolidinedicarboxylic acid 2-(dihydrogen phosphate); 4-Phosphono-L-proline; 4-Phosphonoproline; Proline-4-phosphonic acid; 4-PP; Phosphoproline
EINECS	Contact for details

Quality Control

Every batch of our 4-Phosphorylproline is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure product integrity and traceability. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting compliance with research and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.