Description

1-(2-Cyanoethyl)-5-Oxo-L-Proline is a specialized proline derivative featuring a cyanoethyl group at the 1-position and a ketone at the 5-position. This unique molecular structure makes it a valuable chiral building block and intermediate for advanced organic synthesis, particularly in the development of pharmaceuticals and bioactive compounds. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for creating novel molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, including protease inhibitors and other enzyme-targeted therapeutics.
• Peptidomimetics Research: Used to introduce constrained conformations and specific functional groups into peptide analogs to enhance stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for developing advanced active ingredients with specific stereochemical requirements.
• Bioconjugation Chemistry: The reactive ketone and cyano groups can be utilized for site-specific labeling and conjugation in biopharmaceutical development.
• Asymmetric Catalysis Ligand Precursor: Potential use in the synthesis of novel chiral ligands for asymmetric synthesis applications.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	1-(2-Cyanoethyl)-5-Oxo-L-Proline
CAS No.	41563-94-4
Molecular Formula	C₈H₁₀N₂O₃
Molecular Weight	182.18 g/mol
Synonyms	5-Oxo-1-(2-cyanoethyl)-L-proline; L-Proline, 1-(2-cyanoethyl)-5-oxo-; 1-(2-Cyanoethyl)-5-oxoproline; (S)-1-(2-Cyanoethyl)-5-oxopyrrolidine-2-carboxylic acid; 5-Oxo-1-(2-cyanoethyl)proline; NSC 334365; Pyrrolidine-2-carboxylic acid, 1-(2-cyanoethyl)-5-oxo-, (S)-
EINECS	Contact for details

Quality Control

Our 1-(2-Cyanoethyl)-5-Oxo-L-Proline is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, identity confirmation by IR and NMR spectroscopy, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.