Description

Tetrahydropteroylpentaglutamate CAS NO 41520-73-4 is a high-purity, polyglutamated derivative of folic acid, representing a critical biochemical intermediate. This compound is essential for research and development in advanced pharmaceutical and nutritional science due to its role in one-carbon metabolism and cellular processes. It is primarily required by manufacturers and research institutions in the pharmaceutical, nutraceutical, and life science sectors for the development of targeted therapeutics, diagnostic assays, and high-grade nutritional supplements.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of advanced folate-based drugs and targeted cancer therapeutics.
• Biochemical Research: Used as a critical standard and reagent in enzymatic studies, metabolic pathway analysis, and folate biochemistry research.
• Diagnostic Development: Employed in the formulation of calibration standards and reagents for clinical diagnostic kits measuring folate levels and related metabolites.
• Nutraceutical Formulation: Incorporated into high-end, specialized nutritional supplements designed for enhanced bioavailability and metabolic support.
• Cell Culture Media: Used as a defined component in specialized cell culture media for the growth of fastidious cell lines in biomanufacturing.
• Enzyme Substrate: Acts as a specific substrate for enzymes like folylpolyglutamate synthetase (FPGS) in kinetic and inhibition studies.

Basic Information

Product Name	Tetrahydropteroylpentaglutamate
CAS No.	41520-73-4
Molecular Formula	C₃₈H₄₈N₁₂O₁₈
Molecular Weight	960.86 g/mol
Synonyms	Pteroylpentaglutamic Acid; Tetrahydropteroylpentaglutamic Acid; 5,6,7,8-Tetrahydropteroyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl-L-glutamic Acid; H4PteGlu5; Tetrahydrofolylpentaglutamate; Folate Pentaglutamate, Tetrahydro Form; NSC 113930
EINECS	Contact for details

Quality Control

Our Tetrahydropteroylpentaglutamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for research and production use. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC/UV)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.