Description

Z-Val-Ile-Oh CAS NO 41486-97-9 is a protected dipeptide derivative, specifically the C-terminal carboxylic acid of the Z-protected Val-Ile sequence. This compound serves as a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and sequence. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, protease inhibitors, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key raw material in the solid-phase and solution-phase synthesis of peptide-based drugs and candidates.
• Protease Inhibitor Research: Used as a substrate analog or building block in the design and study of inhibitors for enzymes like elastase and other serine proteases.
• Peptidomimetic Development: Essential for constructing non-natural peptide backbones and modified amino acid sequences to enhance metabolic stability and bioavailability.
• Bioconjugation: The carboxylic acid terminus allows for coupling to other molecules, carriers, or solid supports for creating labeled peptides or affinity probes.
• Chemical Biology Tool: Employed in studying protein-protein interactions and signal transduction pathways involving peptide recognition.
• Custom Peptide Synthesis: A fundamental component for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Z-Val-Ile-Oh
CAS No.	41486-97-9
Molecular Formula	C₂₂H₃₄N₂O₅
Molecular Weight	406.52 g/mol
Synonyms	N-(Benzyloxycarbonyl)-L-valyl-L-isoleucine; Z-L-Val-L-Ile-OH; CBZ-Val-Ile-OH; N-CBZ-L-valyl-L-isoleucine; (2S,3S)-2-[[(2S)-2-[[(Benzyloxy)carbonyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoic acid; Benzyl N-[(2S)-1-[[(1S,2S)-1-carboxy-2-methylpentyl]amino]-3-methyl-1-oxobutan-2-yl]carbamate; Z-Val-Ile; N-Cbz-L-Valyl-L-Isoleucine
EINECS	Contact for details

Quality Control

Our Z-Val-Ile-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.