Description

4-(Trifluoromethyl)Cinnamic Aldehyde is a high-value fluorinated aromatic aldehyde building block, distinguished by its trifluoromethyl group which imparts unique electronic and lipophilic properties. This compound is essential for synthesizing advanced intermediates where enhanced metabolic stability and bioavailability are required. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas, where the CF₃ group is a critical pharmacophore.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its ability to modify biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), enhancing charge transport and stability.
• Advanced Polymer Chemistry: Incorporated into specialty polymers and coatings to confer specific properties like chemical resistance, low surface energy, and improved weatherability.
• Fluorescent Probe & Dye Development: Utilized in the design of fluorophores and molecular probes for bio-imaging and diagnostic applications due to its aromatic aldehyde functionality.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures.

Basic Information

Product Name	4-(Trifluoromethyl)Cinnamic Aldehyde
CAS No.	41317-83-3
Molecular Formula	C₁₀H₇F₃O
Molecular Weight	200.16 g/mol
Synonyms	3-[4-(Trifluoromethyl)phenyl]prop-2-enal; 4-(Trifluoromethyl)cinnamaldehyde; (E)-3-[4-(Trifluoromethyl)phenyl]acrylaldehyde; p-Trifluoromethylcinnamaldehyde; 4-Trifluoromethylcinnamic Aldehyde; (E)-4-(Trifluoromethyl)cinnamaldehyde; 2-Propenal, 3-[4-(trifluoromethyl)phenyl]-; Cinnamaldehyde, 4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethyl)Cinnamic Aldehyde is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include data from GC, HPLC, NMR, and IR spectroscopy. Our production adheres to cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep away from strong oxidizing agents, strong bases, and reducing agents. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.