Description

5-Pyrimidinecarbonyl Chloride (7Ci,9Ci) is a high-purity, reactive heterocyclic acid chloride derivative. This compound serves as a critical versatile building block in advanced organic synthesis, enabling the efficient introduction of the pyrimidinecarbonyl moiety. It is primarily utilized by pharmaceutical, agrochemical, and specialty chemical research and development teams for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for nucleoside analogs and kinase inhibitors.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Used to prepare functionalized pyrimidine-based ligands for metal complexes and catalysts.
• Material Science: Monomer or precursor for creating specialized polymers and advanced organic materials.
• Peptide & Bioconjugate Chemistry: Employed for the acylation of amines in peptides or biomolecules to attach pyrimidine-based tags or functionalities.
• Custom Synthesis & Contract Research: Essential for research organizations engaged in custom synthesis and discovery chemistry projects.

Basic Information

Product Name	5-Pyrimidinecarbonyl Chloride (7Ci,9Ci)
CAS No.	40929-48-4
Molecular Formula	C5H3ClN2O
Molecular Weight	142.55 g/mol
Synonyms	Pyrimidine-5-carbonyl chloride; 5-Pyrimidinecarboxylic acid chloride; 5-Carboxypyrimidine chloride; 5-Chlorocarbonylpyrimidine; Pyrimidin-5-ylcarbonyl chloride; 5-Pyrimidinecarbonyl chloride; 5-(Chloroformyl)pyrimidine; Isonicotinoyl chloride analog (pyrimidine)
EINECS	Contact for details

Quality Control

Every batch of 5-Pyrimidinecarbonyl Chloride is manufactured and tested under strict quality management systems. We ensure high purity and batch-to-batch consistency through comprehensive analytical protocols including HPLC, NMR, and titration. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and reactive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.