Description

2-Chloro-5-(Trifluoromethyl)Phenol is a versatile halogenated phenol derivative, serving as a critical synthetic intermediate in advanced chemical manufacturing. Its value lies in the unique combination of the phenolic hydroxyl group and the electron-withdrawing chloro- and trifluoromethyl substituents, which make it a valuable building block for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Building block for herbicides, fungicides, and insecticides, where the chloro and trifluoromethyl groups contribute to pesticidal activity and environmental persistence.
• Liquid Crystal & OLED Materials: Used in the development of advanced electronic display components and organic light-emitting diodes due to its aromatic structure and halogen substituents.
• Polymer Modification: Acts as a monomer or additive to introduce specific functional groups into polymer chains, altering properties like solubility, thermal stability, and chemical resistance.
• Dye & Pigment Manufacturing: Intermediate for producing specialized dyes and pigments where halogenated phenols are required for specific color fastness and properties.
• Research & Development: Valuable reagent in organic synthesis for academic and industrial R&D, enabling the exploration of new chemical entities and reaction pathways.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Phenol
CAS No.	40889-91-6
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-cresol; 2-Chloro-α,α,α-trifluoro-4-methylphenol; 5-Chloro-2-hydroxybenzotrifluoride; 2-Chloro-5-(trifluoromethyl)phenol; 2-Chloro-α,α,α-trifluoro-p-cresol; 4-Chloro-3-hydroxybenzotrifluoride; 2-Chloro-5-trifluoromethylphenol; 3-Trifluoromethyl-4-chlorophenol
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Phenol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment upon request, providing full traceability and quality assurance for your processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening containers to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.