Description

3-(1,1-Difluoroethyl)Aniline is a specialized aromatic amine derivative featuring a difluoroethyl substituent, serving as a high-value building block in advanced organic synthesis. This compound matters for its role in introducing fluorine-containing motifs, which are critical for modulating the physicochemical and biological properties of target molecules. Pharmaceutical, agrochemical, and material science researchers need this intermediate for developing novel active ingredients and functional materials with enhanced stability and performance.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the difluoroethyl group improves lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing charge transport and thermal properties.
• Polymer Modification: Incorporated as a functional monomer to produce specialty polymers with unique surface characteristics and chemical resistance.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to construct complex nitrogen-containing heterocycles.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) in medicinal chemistry and material science R&D.

Basic Information

Product Name	3-(1,1-Difluoroethyl)Aniline
CAS No.	40788-05-4
Molecular Formula	C8H9F2N
Molecular Weight	157.16 g/mol
Synonyms	3-(1,1-Difluoroethyl)benzenamine; 1-(3-Aminophenyl)-1,1-difluoroethane; m-(1,1-Difluoroethyl)aniline; 3-Amino-α,α-difluoroethylbenzene; Benzenamine, 3-(1,1-difluoroethyl)-; 40788-05-4; α,α-Difluoro-m-ethylaniline
EINECS	Contact for details

Quality Control

Our 3-(1,1-Difluoroethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.