Description

2,2-Dimethylpropionic Acid (2R)-2α-(Acetoxymethyl)-2,3,3Aβ,9Aβ-Tetrahydro-6-Oxo-6H-Furo[2',3':4,5]Oxazolo[3,2-A]Pyrimidin-3β-Yl Ester is a high-purity, complex organic ester with a defined stereochemistry, serving as a critical advanced intermediate in pharmaceutical synthesis. Its precise molecular architecture makes it invaluable for constructing sophisticated active pharmaceutical ingredients (APIs), particularly in specialized therapeutic areas. This compound is essential for research institutions and manufacturers engaged in the development of novel, high-value pharmaceutical compounds, where structural integrity and purity are paramount.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex, biologically active molecules and novel APIs.
• Antiviral Drug Research: Potential precursor in the development of nucleoside/nucleotide analog-based antiviral therapies.
• Oncology Research: Used in the synthetic pathways for experimental chemotherapeutic agents and targeted cancer treatments.
• Process Chemistry & Scale-Up: Employed in process research and development (PR&D) and pilot-scale manufacturing for new drug candidates.
• Asymmetric Synthesis: Utilized as a stereochemically defined reagent in catalytic asymmetric reactions to induce chirality in final products.
• Academic & Contract Research: Serves as a reference standard and starting material in academic research and contract research organizations (CROs) for medicinal chemistry programs.

Basic Information

Product Name	2,2-Dimethylpropionic Acid (2R)-2α-(Acetoxymethyl)-2,3,3Aβ,9Aβ-Tetrahydro-6-Oxo-6H-Furo[2',3':4,5]Oxazolo[3,2-A]Pyrimidin-3β-Yl Ester
CAS No.	40773-09-9
Molecular Formula	C17H22N2O7
Molecular Weight	366.37 g/mol
Synonyms	(2R)-2α-(Acetoxymethyl)-2,3,3aβ,9aβ-tetrahydro-6-oxo-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3β-yl pivalate; Pivalic Acid (2R)-2α-(Acetoxymethyl)-2,3,3aβ,9aβ-tetrahydro-6-oxo-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3β-yl Ester; 3β-Pivaloyloxymethyl-5-fluoro-2'-deoxyuridine Derivative Intermediate; FdUrd Pivaloyloxymethyl Ester Derivative; 5-Fluoro-2'-deoxyuridine 3β-POM Ester Analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical methods including HPLC for purity and chiral assay, NMR for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.