Description

Fmoc-2,2,6,6-Tetramethylpiperidine-n-Oxyl-4-Amino-4-Carboxylic Acid CAS NO 40761-70-4 is a specialized, spin-labeled amino acid derivative designed for advanced peptide and protein research. This compound is critical for introducing a stable nitroxide radical (TEMPO) into synthetic peptide chains, enabling sophisticated structural and dynamic studies using techniques like Electron Paramagnetic Resonance (EPR) spectroscopy. It is an essential building block for biochemists and pharmaceutical researchers focused on probing protein folding, conformational changes, and molecular interactions.

Application

• Site-Directed Spin Labeling (SDSL) for EPR spectroscopy studies of protein structure and dynamics.
• Peptide & Protein Engineering to incorporate stable radical probes into synthetic sequences.
• Biophysical Research investigating conformational changes, folding pathways, and macromolecular interactions.
• Drug Discovery Platforms for studying ligand-receptor binding and allosteric mechanisms.
• Material Science applications in developing smart biomaterials and biosensors.
• Academic & Industrial R&D in structural biology and medicinal chemistry.

Basic Information

Product Name	Fmoc-2,2,6,6-Tetramethylpiperidine-n-Oxyl-4-Amino-4-Carboxylic Acid
CAS No.	40761-70-4
Molecular Formula	C25H28N2O5
Molecular Weight	436.50 g/mol
Synonyms	Fmoc-TOAC; Fmoc-2,2,6,6-Tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic Acid; N-α-Fmoc-4-amino-4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl; Fmoc-4-amino-TEMPO-4-carboxylic Acid; Fmoc-4-ATPC; TOAC-Fmoc; Fmoc-TEMPO-amino acid; Spin-labeled Fmoc-amino acid
EINECS	Contact for details

Quality Control

Our Fmoc-TOAC is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for production and control, ensuring reliability for pharmaceutical and advanced biophysical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (by NMR)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.