Description

H-Thr(Tbu)-Nh2 Hcl is a protected amino acid derivative, specifically the hydrochloride salt of O-tert-butyl-L-threonine amide. This compound serves as a crucial building block (Fmoc/Boc-protected) in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for drug discovery and development.

Application

• Peptide Synthesis Intermediate: A key raw material for the controlled incorporation of threonine residues into peptide chains during SPPS (Solid-Phase Peptide Synthesis).
• Pharmaceutical Research: Used in the discovery and development of novel therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation & Labeling: Serves as a precursor for creating modified peptides with specific functional groups for conjugation with drugs, dyes, or biomarkers.
• GPCR Ligand Development: Employed in the synthesis of peptide-based ligands for G-protein-coupled receptors (GPCRs), a major drug target class.
• Antibiotic & Antimicrobial Peptide (AMP) Synthesis: A component in the production of synthetic antimicrobial peptides for research and development.
• Biochemical Reagent: Used as a standard or reference compound in analytical laboratories for method development and quality control.

Basic Information

Product Name	H-Thr(Tbu)-Nh2 Hcl
CAS No.	40738-21-4
Molecular Formula	C8H19ClN2O2
Molecular Weight	210.70 g/mol
Synonyms	O-tert-Butyl-L-threonine amide hydrochloride; L-Threonine, O-(1,1-dimethylethyl)-, amide, hydrochloride (1:1); H-L-Thr(O-t-Bu)-NH2·HCl; (2S,3R)-2-Amino-3-[(2-methylpropan-2-yl)oxy]butanamide hydrochloride; tert-Butyl L-threoninate amide hydrochloride; Fmoc-Thr(tBu)-NH2 precursor; Boc-Thr(tBu)-NH2 precursor; Protected L-threonine amide HCl salt
EINECS	Contact for details

Quality Control

Our H-Thr(Tbu)-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredient (API) starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.