Description

5-Iodohistidine is a halogenated derivative of the essential amino acid L-histidine, featuring an iodine atom at the 5-position of the imidazole ring. This specific modification makes it a valuable biochemical building block and research tool for studying enzyme mechanisms, protein structure, and iodine metabolism. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors. The compound is supplied with a high level of purity to meet the stringent requirements of advanced research and development applications.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for histidine-decarboxylase and other histidine-related enzymes.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel drug candidates and diagnostic agents.
• Proteomics & Protein Labeling: Acts as a site-specific label for tracking protein interactions, folding, and localization due to the iodine moiety.
• Metabolic Pathway Studies: Employed in research investigating histidine and iodine metabolism in biological systems.
• Radiopharmaceutical Development: A potential precursor for compounds where the iodine-127 can be replaced with radioactive isotopes like I-125 or I-131 for imaging or therapy.
• Peptide Synthesis: Incorporated into custom peptides to modify their structure, stability, or binding properties for research purposes.

Basic Information

Product Name	5-Iodohistidine
CAS No.	40649-71-6
Molecular Formula	C6H8IN3O2
Molecular Weight	281.05 g/mol
Synonyms	5-Iodo-L-histidine; (2S)-2-Amino-3-(5-iodo-1H-imidazol-4-yl)propanoic acid; L-Histidine, 5-iodo-; 5-Iodo-1H-imidazole-4-propanoic acid, α-amino-, (S)-; 5-IH; 5-Iodoimidazolealanine
EINECS	Contact for details

Quality Control

Our 5-Iodohistidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality systems are designed to support applications requiring high-purity biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.