Description

Pglu-His-Pro Amide Acetate Salt is a synthetic peptide derivative of the thyrotropin-releasing hormone (TRH) tripeptide, where the C-terminal is modified to an amide and the compound is presented as an acetate salt. This modification enhances its stability and makes it a valuable biochemical tool for research into neuroendocrine pathways and peptide hormone activity. It is primarily utilized by research institutions and pharmaceutical development companies focusing on neuroscience, endocrinology, and metabolic disorders.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of the thyrotropin-releasing hormone (TRH) receptor and its signaling pathways.
• Neuroscience Studies: Investigated for its potential neuromodulatory and neuroprotective effects in preclinical models.
• Pharmaceutical Development: Serves as a key intermediate or lead compound in the development of novel neuroendocrine therapeutics.
• Diagnostic Reagent Manufacturing: May be incorporated into diagnostic kits or assays for research purposes related to thyroid function.
• Academic Research: Employed in university and institutional labs for teaching and fundamental research in peptide chemistry and hormone biology.

Basic Information

Product Name	Pglu-His-Pro Amide Acetate Salt
CAS No.	40216-95-3
Molecular Formula	C16H24N6O4 • xC2H4O2
Molecular Weight	364.41 g/mol (free base)
Synonyms	Pyroglutamyl-Histidyl-Proline Amide Acetate; TRH Amide Acetate; L-Pyroglutamyl-L-histidyl-L-prolinamide Acetate; pGlu-His-Pro-NH2 Acetate; Thyrotropin-Releasing Hormone Amide Acetate; Protirelin Amide Acetate; (PyroGlu-His-Pro)NH2 Acetate
EINECS	Contact for details

Quality Control

Our Pglu-His-Pro Amide Acetate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and acetates. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Acetate Content (Titration)	Reported on COA
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.