Description

4-Chloro-2-Methylpyrimidine is a versatile halogenated pyrimidine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its reactive chlorine atom and the pyrimidine scaffold, enabling precise molecular construction for high-value target compounds. This building block is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and kinase inhibitor drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the pyrimidine core is a common bioactive motif.
• Chemical Research & Development: Employed as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Acts as a monomer or functionalization agent in the creation of specialty polymers and organic electronic materials.
• Dye & Pigment Manufacturing: Serves as an intermediate for synthesizing complex heterocyclic dyes and colorants.

Basic Information

Product Name	4-Chloro-2-Methylpyrimidine
CAS No.	4994-86-9
Molecular Formula	C5H5ClN2
Molecular Weight	128.56 g/mol
Synonyms	2-Methyl-4-chloropyrimidine; 4-Chloro-2-picoline; 4-Chloro-2-methylpyrimidine; 2-Methyl-4-chloro-1,3-diazine; Pyrimidine, 4-chloro-2-methyl-; 4-Chloro-2-methyl-1,3-diazine
EINECS	225-658-6

Quality Control

Our 4-Chloro-2-Methylpyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from GC, HPLC, and NMR testing. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.