Description

4-Chloro-2-(Methylthio)Pyrimidine is a versatile halogenated heterocyclic building block essential for advanced organic synthesis. Its core value lies in its bifunctional reactivity, where the chloro and methylthio groups serve as distinct handles for selective substitution and cross-coupling reactions. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other biologically active pyrimidine derivatives.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and insecticides that incorporate the pyrimidine scaffold.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential building block for the development of organic electronic materials, ligands for catalysis, and specialty polymers.
• Cross-Coupling Reactions: The chloro group is amenable to palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig), while the methylthio group can be modified or displaced.
• Nucleoside Chemistry: Fundamental intermediate for modifying the heterocyclic base in the design of antiviral or anticancer nucleoside analogs.

Basic Information

Product Name	4-Chloro-2-(Methylthio)Pyrimidine
CAS No.	4944-90-8
Molecular Formula	C5H5ClN2S
Molecular Weight	160.62 g/mol
Synonyms	2-(Methylthio)-4-chloropyrimidine; 4-Chloro-2-methylsulfanylpyrimidine; 4-Chloro-2-methylmercaptopyrimidine; 4-Chloro-2-(methylthio)pyrimidine; 2-Methylthio-4-chloropyrimidine; 4-Chloro-2-(methylsulfanyl)pyrimidine; 4-Chloro-2-(methylmercapto)pyrimidine; Pyrimidine, 4-chloro-2-(methylthio)-
EINECS	225-580-7

Quality Control

Our 4-Chloro-2-(Methylthio)Pyrimidine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and assurance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.