Description

D-Alanine n-Carboxyanhydride is a high-purity, reactive cyclic anhydride derivative of the non-natural D-enantiomer of the amino acid alanine. This compound serves as a critical chiral building block for the controlled synthesis of polypeptides and other advanced biomaterials with specific stereochemistry. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise control over polymer sequence and three-dimensional structure. The product is supplied under strict quality control to ensure optimal reactivity and purity for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key monomer for the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics featuring D-amino acids.
• Biomaterials Research: Synthesis of custom polypeptides and polyamino acids with engineered properties for drug delivery systems, tissue engineering scaffolds, and biodegradable polymers.
• Enantioselective Catalysis: Used in the preparation of chiral ligands, catalysts, and auxiliaries for asymmetric synthesis.
• Surface Modification: Grafting of peptide sequences onto surfaces to create bioactive coatings with specific cell-adhesion or anti-fouling properties.
• Chemical Biology Probes: Incorporation into peptide-based probes for studying enzyme mechanisms, protein-protein interactions, and cellular processes.
• Academic & Industrial R&D: Fundamental research in polymer chemistry, supramolecular assembly, and the development of new synthetic methodologies.

Basic Information

Product Name	D-Alanine n-Carboxyanhydride
CAS No.	4829-14-5
Molecular Formula	C4H5NO3
Molecular Weight	115.09 g/mol
Synonyms	D-Alanine NCA; (R)-2-Methyl-2,5-dihydro-1,3-oxazole-2,4-dione; D-Alanine N-Carboxy Anhydride; D-Ala-NCA; N-Carboxy-D-alanine anhydride; D-2-Methyl-2,5-oxazolidinedione; D-Alanine, N-carboxy-, anhydride; D-Alanine cyclic N-carboxyanhydride
EINECS	Contact for details

Quality Control

Our D-Alanine n-Carboxyanhydride is manufactured under controlled conditions to ensure batch-to-batch consistency and high chemical purity suitable for research and GMP applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to confirm identity and assay. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as purity, moisture content, and residual solvents. We adhere to stringent internal quality standards to support your critical development and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening to prevent hydrolysis and loss of reactivity. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.