Description

Fmoc-Glu-Otbu CAS NO 4793-07-7 is a protected amino acid derivative, specifically the tert-butyl ester of Fmoc-glutamic acid, which serves as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing orthogonal protection for the glutamic acid side chain, enabling the controlled synthesis of complex peptides and peptide mimetics. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the controlled, sequential assembly of peptide chains on resin supports.
• Pharmaceutical R&D: Used in the research and development of novel peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Bioconjugation: Serves as a precursor for introducing glutamic acid residues into biomolecules for labeling or functionalization.
• Production of Glutamate-Containing Peptides: Specifically enables the incorporation of glutamic acid with a protected side chain, which is crucial for peptides where the carboxylic acid functionality must be revealed selectively during synthesis.
• Academic & Institutional Research: A fundamental reagent in university and institutional laboratories studying protein structure, function, and peptide chemistry.

Basic Information

Product Name	Fmoc-Glu-Otbu
CAS No.	4793-07-7
Molecular Formula	C24H27NO6
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-L-glutamic acid 5-tert-butyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 1-tert-butyl ester; Fmoc-Glu(OtBu)-OH; Fmoc-L-Glu(OtBu)-OH; Nα-Fmoc-L-glutamic acid γ-tert-butyl ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]pentanedioic acid 5-tert-butyl ester; Fmoc-Glutamic acid tert-butyl ester; Fmoc-Glu(OtBu)
EINECS	Contact for details

Quality Control

Our Fmoc-Glu-Otbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Specific Rotation	-14.0° to -16.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.