Description

o-Benzyl-L-Serine is a protected derivative of the essential amino acid L-serine, featuring a benzyl group on the hydroxyl side chain. This modification is crucial for its primary role as a key chiral building block in the synthesis of complex peptides and pharmaceutical intermediates. It is particularly valuable for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, optically active components for advanced drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) where the benzyl group protects the serine hydroxyl during coupling, preventing side reactions.
• Bioconjugation & Linker Chemistry: Serves as a spacer or linker molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates due to its functional groups.
• Research & Development: Employed in academic and industrial R&D for studying enzyme mechanisms, protein engineering, and as a standard in analytical method development.
• Fine Chemical Synthesis: A versatile building block for creating non-natural amino acids, custom peptides, and other specialty organic compounds.

Basic Information

Product Name	o-Benzyl-L-Serine
CAS No.	4726-96-9
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	O-Benzyl-L-serine; (S)-2-Amino-3-(benzyloxy)propanoic acid; L-Serine, O-benzyl-; H-Ser(Bzl)-OH; Benzyl L-serinate; NSC 3349; Bzl-Ser-OH; (2S)-2-Azaniumyl-3-(phenylmethoxy)propanoate
EINECS	225-222-6

Quality Control

Our o-Benzyl-L-Serine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in H₂O)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.