Description

Z-Glu(Ome)-OH is a protected amino acid derivative, specifically the benzyloxycarbonyl (Z) protected form of L-glutamic acid 1-methyl ester. This compound serves as a crucial building block in peptide synthesis, where its orthogonal protecting groups allow for selective deprotection and controlled chain elongation. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers involved in developing novel therapeutic peptides and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for incorporating glutamic acid residues with side-chain protection.
• Solution-Phase Peptide Synthesis: For the controlled synthesis of complex peptide sequences in research and development.
• Pharmaceutical Intermediates: In the production of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation: As a modified amino acid for creating peptide-protein or peptide-small molecule conjugates.
• Biochemical Research: Used in studying enzyme-substrate interactions and protein structure-function relationships.
• Combinatorial Chemistry: As a building block in libraries for drug discovery and high-throughput screening.

Basic Information

Product Name	Z-Glu(Ome)-OH
CAS No.	4652-65-7
Molecular Formula	C14H17NO6
Molecular Weight	295.29 g/mol
Synonyms	N-Carbobenzoxy-L-glutamic acid 1-methyl ester; Z-L-Glutamic acid 1-methyl ester; Nα-Cbz-L-glutamic acid α-methyl ester; (S)-2-((Benzyloxy)carbonylamino)pentanedioic acid 1-methyl ester; Cbz-Glu-OMe; N-Cbz-L-glutamic acid α-methyl ester; Benzyl N-[(1S)-4-methoxy-1,4-dioxobutyl]carbamate; L-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 1-methyl ester
EINECS	Contact for details

Quality Control

Our Z-Glu(Ome)-OH is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, chiral integrity, and impurity profiles. Our quality commitment aligns with standards relevant for GMP starting material and research-grade chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.