Description

Z-D-Val-Osu is a protected amino acid derivative widely used as a key building block in the synthesis of complex peptides and pharmaceutical intermediates. Its primary value lies in providing a reactive ester form of D-valine, which is crucial for efficient and controlled peptide bond formation, particularly in solid-phase peptide synthesis (SPPS). This high-purity reagent is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require precise stereochemistry and high coupling yields for producing therapeutic peptides and chiral molecules.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for the controlled incorporation of D-valine into peptide chains during the development of novel therapeutic peptides and peptidomimetics.
• Solid-Phase Peptide Synthesis (SPPS): Used as an activated ester for efficient, racemization-free coupling in automated and manual peptide assembly.
• Protecting Group Strategy: Serves as a Z (benzyloxycarbonyl)-protected valine derivative, allowing for orthogonal deprotection in multi-step synthetic sequences.
• Chiral Building Block Production: Provides a source of enantiomerically pure D-valine for the synthesis of non-natural amino acids and other chiral compounds.
• Bioconjugation and Labeling: Facilitates the site-specific attachment of valine-containing motifs or labels to proteins, antibodies, or other biomolecules.
• Academic and R&D Laboratories: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and the exploration of new bioactive peptide sequences.

Basic Information

Product Name	Z-D-Val-Osu
CAS No.	4467-55-4
Molecular Formula	C15H18N2O5
Molecular Weight	306.32 g/mol
Synonyms	Nα-Z-D-Valine N-Hydroxysuccinimide Ester; N-Carbobenzoxy-D-valine N-hydroxysuccinimide ester; Z-D-Val-OSu; Z-D-Val-ONSu; (R)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanoic acid 2,5-dioxopyrrolidin-1-yl ester; Benzyl (R)-(1-((2,5-dioxopyrrolidin-1-yl)oxy)-3-methyl-1-oxobutan-2-yl)carbamate; D-Valine, N-[(phenylmethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester
EINECS	Contact for details

Quality Control

Our Z-D-Val-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.