Description

(17α)-14-Hydroxy-3,16-Dioxo-5β-Card-20(22)-Enolide CAS NO 4442-31-3 is a high-purity, steroidal lactone compound, also known as a cardenolide derivative, serving as a critical intermediate in advanced pharmaceutical synthesis. Its precise molecular structure makes it an essential building block for the development of potent cardiac glycosides and other specialized active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of cardiovascular therapeutics and novel steroid-based drugs, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of cardiac glycosides and related therapeutic agents.
• Cardiovascular Drug Research: Used in R&D for developing new treatments targeting heart function and related conditions.
• Steroid Chemistry: Serves as a specialized building block for the synthesis of complex steroid derivatives with biological activity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Utilized in studies investigating the mechanism of action of cardenolides on cellular ion channels.
• API Manufacturing: Integrated into Good Manufacturing Practice (GMP) processes for the commercial-scale production of finished dosage forms.

Basic Information

Item	Details
Product Name	(17α)-14-Hydroxy-3,16-Dioxo-5β-Card-20(22)-Enolide
CAS No.	4442-31-3
Molecular Formula	C23H32O5
Molecular Weight	388.50 g/mol
Synonyms	14-Hydroxy-3,16-dioxo-5β-card-20(22)-enolide; 3β,14-Dihydroxy-5β-card-20(22)-enolide-16-one; Cardenolide intermediate; 5β-Card-20(22)-enolide-3,16-dione, 14-hydroxy-; (17α)-14-Hydroxy-3,16-dioxo-5β-card-20(22)-enolide; 14-Hydroxy-3,16-dioxocard-20(22)-enolide
EINECS	Contact for details

Quality Control

Our (17α)-14-Hydroxy-3,16-Dioxo-5β-Card-20(22)-Enolide is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in original packaging and opened only in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.