Description

Pth-Leucine CAS NO 4399-40-0 is a high-purity, protected amino acid derivative, specifically N-(Phenylthiohydantoin)-L-leucine, essential for advanced peptide synthesis and research. This compound serves as a critical building block and analytical intermediate, enabling precise chemical transformations with high selectivity. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in peptide chemistry, proteomics, and analytical method development.

Application

• Peptide Synthesis Intermediate: Used as a protected leucine derivative in solid-phase and solution-phase peptide synthesis.
• Edman Degradation Reagent: Acts as a reference standard or intermediate in the sequential degradation of peptides for amino acid sequence analysis.
• Pharmaceutical Research: Serves as a key precursor in the development and research of novel therapeutic peptides and peptidomimetics.
• Biochemical Analysis: Employed in proteomics research for protein sequencing and characterization studies.
• Organic Synthesis Building Block: Utilized in the synthesis of more complex organic molecules and specialized amino acid derivatives.
• Quality Control Standard: Functions as a high-purity reference material in analytical laboratories for method validation and calibration.

Basic Information

Product Name	Pth-Leucine
CAS No.	4399-40-0
Molecular Formula	C13H16N2O2S
Molecular Weight	264.34 g/mol
Synonyms	N-(Phenylthiohydantoin)-L-leucine; L-Leucine, N-[(phenylamino)thioxomethyl]-; 3-[(Phenylamino)thioxomethyl]-5-isobutyl-2,4-imidazolidinedione; PTH-Leucine; Edman Degradation Product of Leucine; 2-[(Phenylamino)carbonothioyl]amino-4-methylpentanoic acid; 4399-40-0; PTH-L-Leu
EINECS	Contact for details

Quality Control

Our Pth-Leucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a corresponding Certificate of Analysis (COA). We support compliance with cGMP guidelines for pharmaceutical intermediates and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Specific range available on COA
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.