Description

D-2-Amino-3-(5-Hydroxyindolyl)Propionic Acid is a specialized, non-proteinogenic amino acid derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical chiral building block and a key intermediate in the synthesis of complex molecules, particularly those targeting neurological pathways. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, structurally defined intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) disorders.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, metabolic pathway analysis, and neurotransmitter research due to its structural similarity to tryptophan derivatives.
• Peptide Synthesis: Employed as a specialized amino acid analog in the solid-phase or solution-phase synthesis of bioactive peptides and peptidomimetics.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Enzyme Substrate/Inhibitor Studies: Utilized in vitro to study enzyme kinetics, specificity, and inhibition mechanisms of amino acid decarboxylases or hydroxylases.
• Precursor for Fluorescent Probes: Acts as a starting material for synthesizing fluorescently labeled compounds used in cellular imaging and diagnostic assays.

Basic Information

Item	Detail
Product Name	D-2-Amino-3-(5-Hydroxyindolyl)Propionic Acid
CAS No.	4350-07-6
Molecular Formula	C11H12N2O3
Molecular Weight	220.23 g/mol
Synonyms	D-5-Hydroxytryptophan; D-5-HTP; (R)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid; D-5-Hydroxy-L-tryptophan; D-5-Hydroxy-3-indolylalanine; 5-Hydroxy-D-tryptophan; Oxitriptan (D-isomer); 4350-07-6
EINECS	Contact for details

Quality Control

Every batch of D-2-Amino-3-(5-Hydroxyindolyl)Propionic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, with specifications typically covering assay, chiral purity, related substances, and residual solvents. A Certificate of Analysis (COA) is supplied with each shipment, detailing the results against agreed specifications. Our quality commitment supports applications requiring research-grade to cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.