Description

5-Iodo-1H-Pyrimidin-4-One is a halogenated pyrimidinone derivative, a key heterocyclic building block in advanced organic synthesis. Its value lies in its iodine substituent, which provides a versatile handle for further functionalization via cross-coupling reactions, making it indispensable for creating complex molecular architectures. This high-purity intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the development of nucleoside analogs, antiviral agents, and other active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer research.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides, leveraging the pyrimidine core's bioactivity.
• Material Science Research: Serves as a building block for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Cross-Coupling Reactions: The iodine atom is an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to form carbon-carbon bonds.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	5-Iodo-1H-Pyrimidin-4-One
CAS No.	4349-07-9
Molecular Formula	C4H3IN2O
Molecular Weight	221.98 g/mol
Synonyms	5-Iodopyrimidin-4(1H)-one; 5-Iodo-4-hydroxypyrimidine; 4-Hydroxy-5-iodopyrimidine; 5-Iodo-1H-pyrimidin-4-ol; 5-Iodouracil (common name for 5-iodo-2,4-pyrimidinedione, related structure); 5-I-4-OH-Pyrimidine; 4349-07-9 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 5-Iodo-1H-Pyrimidin-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.