Description

4-Oxo-L-Proline is a high-purity, non-proteinogenic amino acid derivative that serves as a critical chiral building block and intermediate in organic synthesis. Its unique pyrrolidone carboxylic acid structure makes it valuable for constructing complex molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly for peptide synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a building block for incorporating modified proline residues into therapeutic and research peptides.
• Biochemical Research: Serves as a precursor or standard in metabolic pathway studies and enzyme inhibition research.
• Asymmetric Synthesis: Employed as a starting material or auxiliary for constructing stereochemically defined compounds.
• Fine Chemical Production: A versatile intermediate in the manufacture of specialty chemicals, flavors, and fragrances.
• Cosmetic Ingredient Synthesis: Used in the production of certain moisturizing and anti-aging compounds.

Basic Information

Product Name	4-Oxo-L-Proline
CAS No.	4347-18-6
Molecular Formula	C5H7NO3
Molecular Weight	129.11 g/mol
Synonyms	L-4-Oxoproline; (S)-4-Oxopyrrolidine-2-carboxylic Acid; L-Pyroglutamic Acid; 5-Oxo-L-proline; L-2-Pyrrolidone-5-carboxylic Acid; PCA; L-Pyroglutamate; 5-Oxoproline
EINECS	224-409-3

Quality Control

Our 4-Oxo-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and standard pharmacopeial identification tests. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with relevant industry and research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-70° to -80° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.