Description

L-Proline, [U-14C] is a uniformly carbon-14 labeled isotopologue of the essential amino acid L-proline, identified by CAS number 4305-67-3. This radiolabeled compound is a critical tool for researchers requiring precise metabolic and pharmacokinetic tracing in biological systems. It is primarily utilized in the pharmaceutical, biotechnology, and agrochemical research sectors for advanced studies in drug metabolism, protein synthesis, and biochemical pathway analysis.

Application

• Metabolic Pathway Tracing: Used as a radiotracer to study proline metabolism, collagen biosynthesis, and related biochemical pathways in vivo and in vitro.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the fate of new drug candidates.
• Proteomics & Protein Labeling: Enables the selective labeling of proteins for structural, functional, and turnover studies using mass spectrometry or autoradiography.
• Agricultural & Plant Science Research: Investigates amino acid uptake, transport, and utilization in plants and soil systems.
• Biomedical Research: Applied in studies of cellular stress response, wound healing, and diseases related to connective tissue and imino acid metabolism.
• Radiochemical Synthesis: Serves as a labeled building block for the synthesis of more complex radiolabeled peptides, pharmaceuticals, or research compounds.

Basic Information

Product Name	L-Proline, [U-14C]
CAS No.	4305-67-3
Molecular Formula	C5H914CO2H
Molecular Weight	~117.1 g/mol (specific activity dependent)
Synonyms	(2S)-Pyrrolidine-2-carboxylic-14C acid; L-(-)-Proline-14C; (S)-Pyrolidine-2-carboxylic-14C acid; U-14C-L-Proline; Proline (U-14C); L-Proline (uniformly labeled with carbon-14); 14C-L-Proline
EINECS	Contact for details

Quality Control

Every batch of L-Proline, [U-14C] is manufactured and analyzed under strict quality systems to ensure high chemical, radiochemical, and enantiomeric purity. Our quality commitment includes verification of specific activity, radionuclidic purity, and chemical identity. A comprehensive Certificate of Analysis (COA) detailing all analytical results, including HPLC and radio-HPLC data, is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container sealed in a dry, inert atmosphere. Follow all applicable local and international regulations for the safe handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98%
Radiochemical Purity	≥ 97%
Specific Activity	Customizable (e.g., 50-60 mCi/mmol)
Solvent (if supplied as solution)	Ethanol/Water or as specified
Enantiomeric Purity	≥ 99% (L-isomer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.