Description

trans-3-Hydroxy-L-Proline is a non-proteinogenic, hydroxylated derivative of the amino acid L-proline, characterized by its specific stereochemistry at the 3-position. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceuticals and bioactive molecules. It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical industries, where precise stereochemical control is paramount for drug efficacy and safety.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of collagenase inhibitors, antiviral agents, and other therapeutic compounds.
• Peptide Synthesis: Used to introduce conformational constraints and enhance the stability or biological activity of synthetic peptides.
• Biochemical Research: Serves as a standard or reagent in studies of collagen metabolism, enzyme inhibition, and amino acid biochemistry.
• Cosmetic & Nutraceutical Ingredients: Potential precursor in the development of pro-collagen synthesis boosters for skincare and health supplement formulations.
• Asymmetric Catalysis: Employed as a ligand or precursor for catalysts in stereoselective organic synthesis.
• Cell Culture Media: Component in specialized media formulations for certain cell lines in biomanufacturing.

Basic Information

Product Name	trans-3-Hydroxy-L-Proline
CAS No.	4298-08-2
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	(2S,3R)-3-Hydroxypyrrolidine-2-carboxylic acid; L-3-Hydroxyproline; (2S,3R)-3-Hydroxyproline; 3-Hydroxy-L-proline; trans-4-Hydroxy-L-proline (common misnomer); Oxoproline derivative; Hydroxyproline isomer; HYP
EINECS	224-309-3

Quality Control

Our trans-3-Hydroxy-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistent performance. We provide Certificates of Analysis (COA) with detailed specifications including assay, enantiomeric purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the original container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-70.0° to -76.0° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.