Description

cis-3-Hydroxy-Dl-Proline is a non-proteinogenic amino acid derivative characterized by a hydroxyl group on the pyrrolidine ring. This compound serves as a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for applications such as peptide synthesis and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those with proline-based scaffolds.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce conformational constraints or modify peptide properties.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development.
• Prodrug Development: Acts as a promoiety to enhance the solubility, stability, or bioavailability of drug molecules.
• Ligand Synthesis: Useful for creating specialized ligands for catalysis or metal chelation in asymmetric synthesis.
• Cosmetic Peptides: A potential component in the synthesis of bioactive peptides for advanced skincare formulations.

Basic Information

Product Name	cis-3-Hydroxy-Dl-Proline
CAS No.	4298-05-9
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	(3R,4S)-3-Hydroxy-4-pyrrolidinecarboxylic acid; (3S,4R)-3-Hydroxy-4-pyrrolidinecarboxylic acid; DL-cis-3-Hydroxyproline; 3-Hydroxy-DL-proline; (cis)-3-Hydroxy-DL-proline; 3-Hydroxypyrrolidine-4-carboxylic acid; (±)-cis-3-Hydroxyproline
EINECS	224-307-4

Quality Control

Our cis-3-Hydroxy-Dl-Proline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.