Description

n-Formyl-L-Methionine is a protected derivative of the essential amino acid L-methionine, where the amino group is blocked by a formyl moiety. This modification is critical for its primary role as a key intermediate in the synthesis of peptides and proteins, particularly in solid-phase peptide synthesis (SPPS) where it prevents unwanted side reactions. It is an essential raw material for pharmaceutical research, biotechnology, and the production of specialized nutritional supplements. The compound is supplied under stringent quality control to ensure batch-to-batch consistency for demanding industrial and research applications.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of therapeutic peptides and modified proteins.
• Biotechnology Research: Used in molecular biology and biochemistry for studying protein structure, function, and enzymatic processes.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative to enable the controlled, sequential assembly of peptide chains.
• Nutritional Science: Investigated for applications in specialized enteral and parenteral nutrition formulations.
• Bioconjugation & Labeling: Utilized in the development of antibody-drug conjugates (ADCs) and other bioconjugates due to its reactive side chain.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC and MS.

Basic Information

Product Name	n-Formyl-L-Methionine
CAS No.	4289-98-9
Molecular Formula	C6H11NO3S
Molecular Weight	177.22 g/mol
Synonyms	Formylmethionine; N-Formylmethionine; L-Methionine, N-formyl-; (S)-2-Formamido-4-(methylthio)butanoic acid; FMET; For-Met-OH; NSC 33426; H-Met(For)-OH
EINECS	224-287-8

Quality Control

Our n-Formyl-L-Methionine is manufactured and tested under a quality management system to ensure it meets the high standards required for pharmaceutical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with various pharmacopeial standards upon request, ensuring reliable integration into your regulated workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-25.0° to -30.0° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.